The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity

Objective: The objective of the current work is to examine protective effects S-methyl methionine sulfonium chloride (MMSC) on brain in galactosamine (GalN)-induced hepatotoxicity rats. Materials and Methods: A total twenty two female Sprague-Dawley rats were randomly assigned into four groups as follows: Group I (n=5), intact control animals; II (n=6), animals that received 50 mg/kg/day MMSC by gavage technique for 3 consecutive days; III injected with a single dose 500 mg/kg GalN intraperitoneally (i.p.); IV (n=6) are same (i.p.) 1 hour after treatment. At end experiments (after 6 hours last treatment), all sacrificed under anaesthesia, tissues dissected out. Results: statistically remarkable increase lipid peroxidation, hydroxyproline, nitric oxide levels, was detected while notable decline activities sodium/potassium ATPase observed group comparison In contrast, alterations reversed when given groups. Conclusion: Consequently, it may be considered has role GalN-induced